Kenny Slaught, via his blog, notes that David Low, a professor in UCSB’s Department of Molecular, Cellular, and Developmental Biology, will head an innovative global health and development research project titled “Strategy for development of enteric pathogen-specific phage”. Low’s research focuses on a ground-breaking platform to fight against serious bacterial pathogens that have become resistant to many once-powerful antibiotics. He will create phage to openly locate and destroy several pathogenic bacteria to prevent enteric diseases in today’s babies. They will engineer different versions of the T2 lytic bacteriophage that tie multiple different regions of the BamA protein found within several pathogenic bacteria, which will ensure they only infect these target bacteria. They will test the different phage for ability to kill pathogenic E. coli and Shigella, and whether they will end up evolving a resistance to drugs.
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